Published November 2, 2026. A study published today in Experimental & Molecular Medicine investigates alternative forms of the prolactin receptor as a potential target in systemic lupus erythematosus. Rodrigues Lima-Junior and colleagues found an increased balance of long versus short receptor isoforms in lupus immune cells. A splice-modulating oligomer reduced the long form while increasing […]
Published November 2, 2026. A Nature Methods paper published today introduces tRIBO-seq, a nanopore sequencing workflow that profiles transfer RNAs associated with active ribosomes, rather than relying only on the cell’s total tRNA pool. Monti and colleagues measured tRNA abundance, chemical modifications and fragmentation in a single experimental workflow. In mammalian cell lines, ribosome-associated profiles […]
Published November 2, 2026. A Cell Death & Disease study published today explores why insulin can improve the durability of experimental mesenchymal stem-cell treatment in mouse models of type 2 diabetes. Hu and colleagues tested umbilical cord-derived mesenchymal stem cells in db/db mice and diet-induced obese mice. Cells alone produced short-term metabolic improvements, whereas combining […]
Published November 1, 2026. A Nature Communications paper published on October 30 presents IDPForge, a machine-learning tool for modeling proteins whose flexible regions adopt many configurations rather than one stable structure. De Castro and colleagues use a transformer-based diffusion model to generate ensembles of structures with individual atoms represented. The method handles fully disordered proteins […]
Published November 1, 2026. A Nature Communications study published on October 30 applies Sequence Display and protein language models to expand the DNA sequences accessible to a compact CRISPR enzyme. Cheng and colleagues mapped how individual and combined mutations alter the activity of SlugCas9 across four related PAM contexts: NNAA, NNAT, NNAC and NNAG. PAMs […]
Published November 1, 2026. A Nature Communications study published on October 31 introduces DeepDelivery, an AI platform that searches human proteins for components capable of supporting engineered mRNA delivery. Xun and colleagues screened the human proteome computationally and nominated 512 candidates. Of 15 selected proteins tested experimentally, 12 supported particle formation and mRNA delivery within […]
Published November 1, 2026. A study published in Nature Communications on October 31 examines how lactate-linked modifications of histone proteins influence blood-forming stem and progenitor cells. Zhou and colleagues found that these immature cells had higher glycolytic activity, lactate levels and histone lactylation than erythroid progenitors. Integrated analyses linked lactylation to more accessible chromatin and […]
Published November 1, 2026. A study published in npj Flexible Electronics on October 31 describes a hydrogel electrode designed to keep noninvasive brain–computer interfaces working during extended wear and movement. Jiang and colleagues created a gradual change in stiffness: a soft surface contacts the scalp, while a firmer region connects to the electronics. A graded […]
Published November 1, 2026. A Nature Communications study published on October 31 maps a molecular interaction involving HERC2 and UBE3A, proteins implicated in Angelman syndrome, Dup15q syndrome and related neurodevelopmental conditions. Demenge and colleagues combined binding measurements, X-ray crystallography and evolutionary sequence comparisons. They identified how a short sequence motif in UBE3A binds the RLD2 […]
Published November 1, 2026. A study published today in Nature Communications investigates whether activating the kinesin protein KIF2C can improve DNA repair and reduce features of premature aging. Macedo and colleagues tested a small-molecule KIF2C agonist in aged cells and cells derived from people with Hutchinson–Gilford progeria syndrome or Down syndrome. They report improved repair […]