Category: Biology
- Early cortical stroke shows no additional Alzheimer’s-model deficits at tested time point in mice ()
Published October 31, 2026. A study published today in Scientific Reports tested whether an early cortical stroke worsens Alzheimer’s-related changes in a mouse model. Under the conditions examined, researchers did not detect additional pathology or cognitive impairment in the transgenic animals. Permanent middle cerebral artery occlusion was induced at four months of age in wild-type […]
- Chronic exercise leaves pathway-specific electrical signatures in the mouse hippocampus ()
Published October 31, 2026. Chronic treadmill exercise leaves a pathway-specific electrical signature in the mouse hippocampus, according to a study published today in Communications Biology. Researchers recorded field potentials in anesthetized male C57BL/6J mice after an exercise protocol. Machine-learning analysis could distinguish experimental groups using activity associated with the lateral perforant path, relying on several […]
- Glioblastoma target GD2 changes with TGF-beta signaling in two cell-line models ()
Published October 31, 2026. GD2, a potential therapeutic target in glioblastoma, can change in opposite directions depending on the tumor cell model and its signaling environment. A study published today in Scientific Reports examined this variability in two laboratory cell lines. Researchers exposed U87-MG and U251-MG cells to TGF-β and measured gangliosides, gene expression, surface […]
- Aging changes memory-associated neuronal ensembles and gene expression in mice ()
Published October 31, 2026. A new study in Nature Communications examines how aging changes the neuronal ensembles involved in memory, often called engrams. Researchers compared contextual fear-memory encoding and recall in young and aged mice. Nuclear tagging and FOS-based activity mapping revealed age-related differences in the activation, distribution and relationships between memory-associated ensembles across brain […]
- Colorectal cancer cells regain proliferation after prolonged glucose deprivation in culture ()
Published October 31, 2026. Some colorectal cancer cells can survive prolonged glucose deprivation and eventually resume dividing, according to laboratory research published October 30 in Cell Death Discovery. When glucose was removed from the culture medium, part of the cell population died. Surviving cells initially entered a dormant, senescence-like state with growth arrest, oxidative stress […]
- Research highlight examines age-specific targets for anti-tumor T cell function ()
Published October 31, 2026. An October 29 research highlight in Cell Research examines why age may matter when selecting targets to improve anti-tumor T cell function. It discusses an earlier Cell study of Dusp5 and Zfp219, rather than reporting a new clinical trial. In the original experiments, single-cell CRISPR screens identified two different routes to […]
- Absorbable cellulose hemostats compared in a small multi-organ pig study ()
Published October 31, 2026. A small preclinical study compared two absorbable oxidized regenerated cellulose materials for controlling bleeding in pigs. The work was published October 29 in Scientific Reports. Sixteen male Bama minipigs were assigned to liver or gastrointestinal bleeding models. Within each model, four animals received StypCel and four received Surgicel Fibrillar, with multiple […]
- Continuous mass photometry follows individual protein interactions for up to an hour ()
Published October 31, 2026. Continuous mass photometry allows researchers to follow individual biomolecules and their interactions for up to an hour. The method was reported October 26 in Nature Methods by researchers at Oxford. Patterned supported lipid bilayers keep tethered proteins within the microscope’s observation area while allowing interaction with molecules in solution. A custom […]
- MARRS recruits endogenous ADAR1 for efficient RNA editing in cells and mice ()
Published October 31, 2026. A new RNA editing system recruits a cell’s own ADAR1 enzyme using engineered RNA aptamers. The platform, called MARRS, was described October 28 in Nature Methods. The researchers combined repeated enzyme-binding aptamers with a circular RNA scaffold. These components engage the Zα domain of ADAR1 p150 and guide adenosine-to-inosine editing at […]
- McGill researchers identify genome-carrying vesicles shed by migrating cancer cells ()
Published October 30, 2026. Researchers at McGill and collaborating institutions have identified large extracellular vesicles released as cancer cells migrate. Their study, published October 28 in Nature Cell Biology, names this population motile vesicles, or MoVes. Measuring approximately 2–5 micrometres, MoVes form at the retracting rear of moving cells. Imaging and molecular analyses distinguish them […]