Category: Ischemia
- Early cortical stroke shows no additional Alzheimer’s-model deficits at tested time point in mice ()
Published October 31, 2026. A study published today in Scientific Reports tested whether an early cortical stroke worsens Alzheimer’s-related changes in a mouse model. Under the conditions examined, researchers did not detect additional pathology or cognitive impairment in the transgenic animals. Permanent middle cerebral artery occlusion was induced at four months of age in wild-type […]
- MCT1 supports mitochondrial lactate use and cardiac resilience in experimental models ()
Published October 30, 2026. A Nature study published October 28 identifies a route by which heart mitochondria use lactate as fuel. Researchers found MCT1, a transporter usually associated with the cell surface, in the inner mitochondrial membrane of mouse and human heart-muscle cells. Working with mitochondrial LDHB, MCT1 supports conversion of lactate into pyruvate and […]
- Mitochondrial peptide delivery supports cryopreserved ovarian grafts in rabbits ()
Published October 29, 2026. A rabbit study explores mitochondrial protection after ovarian tissue cryopreservation and transplantation. Published October 28 in npj Regenerative Medicine, the work tests localized delivery of the antioxidant peptide elamipretide, also called SS31. Ovarian grafts face several sources of injury, including oxidative stress and the interruption and restoration of blood supply. The […]
- Feedback-controlled norepinephrine stabilizes spinal cord perfusion in animal models ()
Published October 29, 2026. A feedback-controlled infusion system aims to stabilize blood flow after spinal cord injury. Routkevitch and colleagues report the preclinical work today in Nature Biomedical Engineering. The system uses local perfusion measurements to adjust norepinephrine delivery, rather than relying solely on arterial blood pressure as a surrogate for the injured tissue’s circulation. […]
- Holographic ultrasound improves therapeutic delivery after stroke in mice ()
Published October 27, 2026. Jia-Ji Pan and colleagues report a focused-ultrasound platform designed to deliver extracellular vesicles and mesenchymal stromal cells to multiple regions bordering an ischemic brain injury. Their study appeared October 25 in Nature Communications as an accepted article awaiting final editorial updates. The system, called HaMBO, combines a single-element ultrasound transducer with […]
- ZO-1 Review Clarifies Evidence for Blood-Brain Barrier Recovery After Ischemia ()
Published October 26, 2026. A review published October 21 in Frontiers in Cell and Developmental Biology examines how the junctional protein ZO-1 changes when the brain loses and then regains blood supply. Bosi Zhou and colleagues argue that the protein’s location and organization matter alongside its overall quantity. ZO-1 helps organize junctions between blood-vessel lining […]
- Sensory Nerve Signal Limits Kidney Ischemia–Reperfusion Injury in Mouse Models ()
Published October 25, 2026. A study in Cell Research identifies a protective interaction between sensory nerves and immune cells in experimental kidney ischemia–reperfusion injury, which occurs when blood flow is interrupted and then restored. Lei Wang and colleagues mapped sensory fibers throughout kidney tissue using tissue clearing and three-dimensional imaging. In mouse experiments, removing TRPV1-positive […]
- Partial cellular reprogramming reduces acute ischemic brain injury in aged mice ()
Published October 24, 2026. A study published October 23 in Aging Cell reports that short cycles of partial cellular reprogramming reduced acute ischemic brain injury in aged mice. Paula R. Mallavibarrena and colleagues used a genetically engineered, inducible mouse model to express the four Yamanaka factors, collectively called OSKM. The animals underwent permanent middle cerebral […]
- Reducing TMEM59 limits ischemic brain injury in mouse experiments ()
Published October 22, 2026. A preclinical study published October 15 in Cell Death & Disease identifies TMEM59 as a potential target for limiting brain injury after interrupted blood flow and subsequent reperfusion. Jinghui Wang and colleagues investigated how TMEM59 interacts with TREM2, a receptor involved in microglial responses. In mouse stroke models, losing TREM2 worsened […]
- Circular RNA-Encoded Protein Limits Neuronal Ferroptosis in Ischemia Models ()
Published October 19, 2026. A circular RNA may protect neurons from a form of cell death associated with chronically reduced brain blood flow. Jiashuo Yang and colleagues report the findings in Communications Biology, published October 14. In mouse and cellular models of chronic cerebral ischemia, the researchers found that circAbcc1 produces a functional protein called […]