Circular RNA-Encoded Protein Limits Neuronal Ferroptosis in Ischemia Models
Published in Brain/Neurology, Ischemia, Journals.
Published October 19, 2026.
A circular RNA may protect neurons from a form of cell death associated with chronically reduced brain blood flow. Jiashuo Yang and colleagues report the findings in Communications Biology, published October 14.
In mouse and cellular models of chronic cerebral ischemia, the researchers found that circAbcc1 produces a functional protein called ABCC1-677aa. Their experiments link this protein to changes in DLX1, a transcription factor that can repress genes involved in defending cells against ferroptosis.
The reported mechanism moves DLX1 from the nucleus into the cytoplasm, relieving repression of Gpx4 and Fsp1. Increased activity of these protective genes was accompanied by reduced lipid peroxidation and iron accumulation, helping limit neuronal ferroptosis in the models studied.
The study highlights a protein-producing role for circular RNA and identifies a possible target for neuroprotection research. These are preclinical results: they do not demonstrate a treatment for human stroke, reverse established brain damage, or establish benefits for cryopreservation. Delivery, safety and effectiveness in people remain to be tested.
Source: Yang and colleagues, Communications Biology, October 14, 2026.