Category: Immunology
- Research highlight examines age-specific targets for anti-tumor T cell function ()
Published October 31, 2026. An October 29 research highlight in Cell Research examines why age may matter when selecting targets to improve anti-tumor T cell function. It discusses an earlier Cell study of Dusp5 and Zfp219, rather than reporting a new clinical trial. In the original experiments, single-cell CRISPR screens identified two different routes to […]
- Kaempferol reduces secondary brain injury measures in a mouse trauma model ()
Published October 31, 2026. Kaempferol reduced several measures of secondary damage after traumatic brain injury in mice, according to a study published October 30 in Scientific Reports. Using a fluid percussion injury model, researchers reported smaller lesions, less neuronal loss and better neurological, motor and cognitive outcomes in treated animals. They also observed reduced leakage […]
- Kidney-derived mitochondrial vesicles link sepsis to lung injury in experimental models ()
Published October 30, 2026. An injured kidney may help spread damage to the lungs during sepsis by releasing extracellular vesicles rich in mitochondrial material, according to new research in Communications Biology. In septic mice and cultured kidney tubular cells, the researchers linked increased vesicle formation to sorting nexin 9. Blocking this process in kidney tubules […]
- CRISPR screen links MYD88–IRAK4 signaling to fungal-toxin damage in pig intestinal cells ()
Published October 30, 2026. A Communications Biology study published October 28 uses a genome-wide CRISPR knockout screen to investigate how deoxynivalenol, a fungal toxin, damages pig intestinal epithelial cells. The screen identified MYD88 and IRAK4 as leading contributors to susceptibility in the cultured-cell system. Exposure activated inflammatory signaling while reducing several antioxidant defenses and increasing […]
- Review examines macrophage lipid metabolism and bone remodeling ()
Published October 30, 2026. A new Bone Research review examines how lipid metabolism in macrophages influences the balance between bone breakdown and formation. The authors discuss fatty-acid oxidation and cholesterol metabolism as regulators of macrophage activation states. These immune-cell states can affect inflammation and the signals that shape bone remodeling. The review also considers emerging […]
- Review examines TNF signaling at the epilepsy brain–heart interface ()
Published October 30, 2026. A new review examines how TNF-related inflammation may connect epilepsy, blood–brain barrier injury and cardiovascular vulnerability. Receptor subtype and tissue context matter: inflammatory and potentially reparative effects differ. The authors integrate epilepsy research with related neurovascular and cardiac studies. They emphasize that direct epilepsy-specific evidence linking TNF signaling to cardiovascular outcomes […]
- 4-octyl itaconate promotes tolerogenic dendritic cells in experimental lupus ()
Published October 30, 2026. A new Cell Death Discovery study investigates 4-octyl itaconate, an itaconate derivative, as a way to alter dendritic-cell behavior in experimental lupus. In a chromatin-induced mouse model, treatment delayed disease onset and reduced proteinuria, anti-DNA autoantibodies and kidney injury. Laboratory and animal experiments indicated that the compound encouraged a tolerogenic dendritic-cell […]
- Aptamer biosensor detects mycoplasma-associated protein in T-cell culture ()
Published October 30, 2026. Researchers describe an electrochemical biosensor for detecting Mycoplasma hyorhinis contamination in human T-cell cultures. The device uses an aptamer that recognizes the microorganism’s p37 protein, offering a route to detection with limited sample preparation. In buffer and T-cell co-culture medium, the reported detection limit was approximately two cells per milliliter, while […]
- Targeted lipid nanoparticles deliver Brec1 mRNA to CD4 T cells in laboratory study ()
Published October 30, 2026. Researchers report a laboratory platform that combines CD4-targeting single-domain antibodies, lipid nanoparticles and messenger RNA encoding the Brec1 recombinase. The goal is to deliver genome-editing machinery to cells relevant to the persistent HIV reservoir. In primary human blood immune cells, the targeted nanoparticles transfected 44% of CD4 T cells under the […]
- Agentic AI helps human reviewers identify immunotherapy adverse events in clinical notes ()
Published October 30, 2026. A Nature Cancer study published October 29 evaluates an AI system that helps reviewers identify immune-related adverse events in oncology notes. It extracts event presence, timing, severity, treatment attribution and diagnostic certainty across six toxicity types. Retrospective testing produced a macro-averaged F1 score of 0.92 for current-event detection, but only 0.66 […]