Review examines TNF signaling at the epilepsy brain–heart interface
Published in Brain/Neurology, Immunology, Journals.
Published October 30, 2026.
A new review examines how TNF-related inflammation may connect epilepsy, blood–brain barrier injury and cardiovascular vulnerability. Receptor subtype and tissue context matter: inflammatory and potentially reparative effects differ.
The authors integrate epilepsy research with related neurovascular and cardiac studies. They emphasize that direct epilepsy-specific evidence linking TNF signaling to cardiovascular outcomes remains limited.
This is a research synthesis, not a treatment trial. It does not establish that TNF blockade prevents arrhythmias or sudden death in epilepsy.
Source: Sha et al., Acta Pharmacologica Sinica. October 30, 2026. DOI: 10.1038/s41401-026-01949-9.