Category: Diseases!
- Perspective examines psychological risk, resilience and support in dementia ()
Published October 25, 2026. A Perspective published in Nature Mental Health on October 23 reviews evidence connecting psychological characteristics with cognitive aging and Alzheimer’s disease and related dementias. Natalie Marchant and colleagues revisit the concept of psychological debt: the possibility that adverse psychological factors contribute to dementia risk over time. The article distinguishes potential risk […]
- Review Explores Immune Control of Breast Cancer Dormancy Across Organs ()
Published October 25, 2026. A new review in npj Breast Cancer examines how the immune system can influence whether disseminated breast cancer cells remain dormant or resume metastatic growth. Hayley M. Sabol and Lucia Borriello consider evidence across four organs: bone, lung, liver and brain. Their synthesis highlights the protective roles that CD8-positive T cells […]
- Y-Chromosome Loss in Blood Linked to Later Macular Degeneration in Men ()
Published October 24, 2026. A new Aging Cell study links mosaic loss of chromosome Y in blood cells with later age-related macular degeneration (AMD), while showing that the strength of the association depends on how chromosome loss is measured. Tianhao Chen and colleagues analyzed 223,051 men in UK Biobank; 8,920 were classified as carrying this […]
- Macrophage Matrix Remodeling Awakens Dormant Breast Cancer Cells in Laboratory Models ()
Published October 24, 2026. A study published in Oncogenesis investigates how immune cells may help dormant breast cancer cells resume growth. Kitti Jenovai and colleagues used three-dimensional cocultures to examine interactions between macrophages, cancer cells and the extracellular matrix surrounding them. In these laboratory systems, macrophages promoted cancer-cell awakening by altering that matrix. The researchers […]
- Gas6 and mitochondrial vesicles linked to calcification in human valve-cell experiments ()
Published October 24, 2026. Research published October 20 in Aging Cell links Gas6 signalling and mitochondrial-derived vesicles to calcification in human heart-valve cells. Yaoyu Zhang and colleagues examined calcific aortic valve disease, in which mineral deposits spread into surrounding valve tissue. Diseased human valve samples and calcifying human valvular interstitial cells showed features associated with […]
- Cartilage Cells Adapt to Protein Stress in a Rare Bone Disorder Model ()
Published October 23, 2026. A new mouse study explores how cartilage cells survive persistent protein-folding stress while bone growth becomes disrupted. Qing Yao and colleagues at the University of Hong Kong published the research in Bone Research on October 16. The team introduced a disease-associated 13-base-pair deletion into the mouse Col10a1 gene to model Schmid […]
- ACSS1 Links Nutrient Overload to Impaired Bone Formation in Mouse Models ()
Published October 20, 2026. Researchers have identified a metabolic pathway that links nutrient overload to impaired bone formation in experimental models. The study by Lu Gao, Zhuolei Yuan and colleagues appeared in Nature Communications on October 20. The team found that excess glucose, alcohol or acetate increased the enzyme ACSS1 in bone marrow skeletal stem […]
- Young Lung Vesicles Support Repair Responses in Aged Mouse Tissue ()
Published October 19, 2026. Extracellular vesicles from young, uninjured mouse lung tissue supported repair-related responses in injured lung slices, including aged tissue, in research published October 12 in npj Regenerative Medicine. Qi Chen and colleagues compared vesicles released by precision-cut lung slices from young and aged mice, with and without injury. These small particles carry […]
- Estradiol–Autophagy Pathway Linked to Vascular Remodeling in Hypertensive Rats ()
Published October 19, 2026. New preclinical research links estradiol signaling to a cellular recycling pathway that may help limit blood-vessel changes associated with hypertension. Miao-Jin Ji and colleagues published the study in Communications Biology on October 17. In spontaneously hypertensive rats, removal of the ovaries worsened hypertension, while estradiol supplementation reduced blood pressure and vascular […]
- Liver Lipid Droplet Size Linked to Distinct Organelle Partnerships ()
Published October 19, 2026. A new study in Communications Biology, published October 18, examines how differently sized lipid droplets in the liver associate with other cellular compartments. These droplets store fats, but their interactions may help determine how those fats are used or recycled. Qiumin Liao and colleagues developed a separation workflow that distinguishes droplets […]