Category: Brain/Neurology
- Early cortical stroke shows no additional Alzheimer’s-model deficits at tested time point in mice ()
Published October 31, 2026. A study published today in Scientific Reports tested whether an early cortical stroke worsens Alzheimer’s-related changes in a mouse model. Under the conditions examined, researchers did not detect additional pathology or cognitive impairment in the transgenic animals. Permanent middle cerebral artery occlusion was induced at four months of age in wild-type […]
- REM sleep wave changes associated with Alzheimer’s pathology and overnight forgetting ()
Published October 31, 2026. A study published October 30 in Nature Communications links changes in REM sleep brain waves with aging, Alzheimer’s-related pathology and overnight forgetting. Across two independent cohorts, researchers observed a shift from faster sawtooth delta waves toward slower, NREM-like delta waves with age, particularly during phasic REM sleep. The shift was associated […]
- Chronic exercise leaves pathway-specific electrical signatures in the mouse hippocampus ()
Published October 31, 2026. Chronic treadmill exercise leaves a pathway-specific electrical signature in the mouse hippocampus, according to a study published today in Communications Biology. Researchers recorded field potentials in anesthetized male C57BL/6J mice after an exercise protocol. Machine-learning analysis could distinguish experimental groups using activity associated with the lateral perforant path, relying on several […]
- Glioblastoma target GD2 changes with TGF-beta signaling in two cell-line models ()
Published October 31, 2026. GD2, a potential therapeutic target in glioblastoma, can change in opposite directions depending on the tumor cell model and its signaling environment. A study published today in Scientific Reports examined this variability in two laboratory cell lines. Researchers exposed U87-MG and U251-MG cells to TGF-β and measured gangliosides, gene expression, surface […]
- Aging changes memory-associated neuronal ensembles and gene expression in mice ()
Published October 31, 2026. A new study in Nature Communications examines how aging changes the neuronal ensembles involved in memory, often called engrams. Researchers compared contextual fear-memory encoding and recall in young and aged mice. Nuclear tagging and FOS-based activity mapping revealed age-related differences in the activation, distribution and relationships between memory-associated ensembles across brain […]
- ATLAS maps 40 million mouse brain cells for comparative spatial biology ()
Published October 31, 2026. ATLAS, a tissue mapping method reported October 30 in Nature Methods, enables large comparative studies of cell distributions in mouse brains. The method learns transcriptional signatures from single-cell RNA sequencing, encodes them within tissue using oligonucleotide probes, and decodes the measurements to infer cell types and imputed transcriptomes. Those inferred transcriptomes […]
- TrUDI extends optical recording of neuronal activity to about 2 mm in mouse brains ()
Published October 31, 2026. TrUDI, a redesigned three-photon microscopy platform, records neuronal activity about 2 millimetres beneath the surface of the mouse brain. The work was published October 28 in Nature Methods and described in a same-day Rockefeller University announcement. Rather than relying on higher average laser power, the team optimized pulse timing and energy, […]
- 7-tesla MRI maps structural and functional organization of human locus coeruleus connections ()
Published October 31, 2026. A study published October 29 in Communications Biology maps how structural and functional connections differ along the human locus coeruleus, a major source of the brain’s norepinephrine. Researchers combined 7-tesla diffusion MRI with resting-state functional MRI. They found that the correspondence between structural and functional connectivity was lowest in the intermediate […]
- Kaempferol reduces secondary brain injury measures in a mouse trauma model ()
Published October 31, 2026. Kaempferol reduced several measures of secondary damage after traumatic brain injury in mice, according to a study published October 30 in Scientific Reports. Using a fluid percussion injury model, researchers reported smaller lesions, less neuronal loss and better neurological, motor and cognitive outcomes in treated animals. They also observed reduced leakage […]
- Review examines TNF signaling at the epilepsy brain–heart interface ()
Published October 30, 2026. A new review examines how TNF-related inflammation may connect epilepsy, blood–brain barrier injury and cardiovascular vulnerability. Receptor subtype and tissue context matter: inflammatory and potentially reparative effects differ. The authors integrate epilepsy research with related neurovascular and cardiac studies. They emphasize that direct epilepsy-specific evidence linking TNF signaling to cardiovascular outcomes […]