Category: Brain/Neurology
- TrUDI extends optical recording of neuronal activity to about 2 mm in mouse brains ()
Published October 31, 2026. TrUDI, a redesigned three-photon microscopy platform, records neuronal activity about 2 millimetres beneath the surface of the mouse brain. The work was published October 28 in Nature Methods and described in a same-day Rockefeller University announcement. Rather than relying on higher average laser power, the team optimized pulse timing and energy, […]
- 7-tesla MRI maps structural and functional organization of human locus coeruleus connections ()
Published October 31, 2026. A study published October 29 in Communications Biology maps how structural and functional connections differ along the human locus coeruleus, a major source of the brain’s norepinephrine. Researchers combined 7-tesla diffusion MRI with resting-state functional MRI. They found that the correspondence between structural and functional connectivity was lowest in the intermediate […]
- Kaempferol reduces secondary brain injury measures in a mouse trauma model ()
Published October 31, 2026. Kaempferol reduced several measures of secondary damage after traumatic brain injury in mice, according to a study published October 30 in Scientific Reports. Using a fluid percussion injury model, researchers reported smaller lesions, less neuronal loss and better neurological, motor and cognitive outcomes in treated animals. They also observed reduced leakage […]
- Review examines TNF signaling at the epilepsy brain–heart interface ()
Published October 30, 2026. A new review examines how TNF-related inflammation may connect epilepsy, blood–brain barrier injury and cardiovascular vulnerability. Receptor subtype and tissue context matter: inflammatory and potentially reparative effects differ. The authors integrate epilepsy research with related neurovascular and cardiac studies. They emphasize that direct epilepsy-specific evidence linking TNF signaling to cardiovascular outcomes […]
- Study links mitochondrial complex IV dysfunction with Alzheimer’s-related damage ()
Published October 30, 2026. A study links mitochondrial complex IV dysfunction with Alzheimer’s-related pathology using human samples and experimental models. Researchers found connections with mitochondrial damage, synaptic loss and amyloid pathology, alongside genetic evidence implicating reduced COX11, a complex IV assembly factor. The findings support further investigation of mitochondrial mechanisms. They do not establish a […]
- MEG study identifies multiple dimensions of cortical excitability ()
Published October 30, 2026. A Communications Biology study compares several indirect measures of cortical excitability using whole-head magnetoencephalography in healthy adults. Recordings were collected at rest and during auditory stimulation at 40 hertz. Rather than finding one interchangeable measure of excitability, the analysis identified six dimensions with limited overlap. The metrics included stimulus synchronization, spectral […]
- Human cortical neurons with extensive genomic abnormalities decline around birth ()
Published October 30, 2026. A Nature study published October 28 reports evidence that neurons carrying extensive DNA copy-number abnormalities become much less common around birth in the human cortex. Researchers sequenced the genomes of 2,357 individual neurons from postmortem brains spanning fetal and postnatal life. Across two sequencing approaches, an average of 25.9% of prenatal […]
- Cryo-EM study examines how human VIAAT packages inhibitory neurotransmitters ()
Published October 30, 2026. A Cell Research study combines cryo-electron microscopy, molecular dynamics simulations and functional experiments to investigate human VIAAT, the transporter that loads inhibitory neurotransmitters into synaptic vesicles. VIAAT packages both GABA and glycine for release by neurons. Understanding how it recognizes these different molecules and couples transport to ions helps explain a […]
- Magnetic muscle tracking supports virtual prosthetic control in three participants ()
Published October 29, 2026. A wearable magnetic sensor array tracks small implanted magnets to measure muscle movement. Shallal and colleagues describe the system today in Nature Sensors, with potential applications in prosthetic control. The platform follows passive magnetic beads measuring three millimeters in diameter inside muscle tissue. Customized electronics provide submillimeter tracking resolution at depths […]
- Fly connectome simulations identify a candidate three-neuron walking rhythm circuit ()
Published October 29, 2026. Simulations built from fly nerve-cord connectomes have identified a candidate circuit for generating walking rhythms. Pugliese and colleagues published the study in Nature on October 28. The researchers simulated the connections in the Drosophila ventral nerve cord and screened descending inputs from the brain. DNg100, a known walking command neuron, was […]