Category: Nanomedicine
- Cell-spreading electrochemical sensor explores single-cell and tumor-cell detection ()
Published November 1, 2026. A Nature Communications study published on October 31 reports an electrochemical platform designed to detect individual cells and explore circulating tumor cell detection. Qi and colleagues found that measurable current arose from redox probes near the cell–electrode interface. Encouraging cells to spread enlarged that interface and amplified the signal. Their platform […]
- Hydrogel and nanocapsules deliver growth factor to arthritic cartilage in preclinical experiments ()
Published October 30, 2026. A new experimental delivery system combines protein-carrying nanocapsules with an injectable hydrogel that adheres to cartilage. The approach, reported in Nature Communications, aims to keep a growth factor inside arthritic joints long enough to reach damaged cartilage. The system, called hydro/nano-bFGF, responds to enzymes associated with diseased tissue. Its hydrogel releases […]
- Targeted lipid nanoparticles deliver Brec1 mRNA to CD4 T cells in laboratory study ()
Published October 30, 2026. Researchers report a laboratory platform that combines CD4-targeting single-domain antibodies, lipid nanoparticles and messenger RNA encoding the Brec1 recombinase. The goal is to deliver genome-editing machinery to cells relevant to the persistent HIV reservoir. In primary human blood immune cells, the targeted nanoparticles transfected 44% of CD4 T cells under the […]
- Ultrasound-triggered bacterial nanocarrier targets pancreatic tumors in preclinical study ()
Published October 29, 2026. An experimental delivery platform combines engineered bacteria, nanoparticles and ultrasound to target pancreatic tumors. Xu and colleagues reported the approach in the Journal of Nanobiotechnology on October 28. The researchers coated attenuated Salmonella VNP20009 with a polymer carrying linked 5-fluorouracil prodrugs, then added manganese carbonate nanoparticles. The bacterial component was designed […]
- Magnetically activated implant nanostructures target biofilms and support bone integration ()
Published October 28, 2026. An experimental implant coating uses externally driven nanoscale motion to tackle infection while supporting bone integration. Chen and colleagues reported the approach in Nature Communications on October 19. The movable magnetic topographic surface, or MMTS, incorporates iron oxide–silver Janus nanoparticles. An electromagnetic field makes the anchored structures oscillate, damaging bacterial membranes […]
- Simulating oil selection for curcumin nanoemulsion design ()
Published October 28, 2026. New research in Scientific Reports uses molecular dynamics simulations to investigate how oil chemistry influences the assembly of potential curcumin carriers. The work addresses formulation design rather than testing a treatment. Bahaman and colleagues compared linoleic acid and oleyl laurate as hydrophobic cores. In the simulated systems, linoleic acid packed more […]
- Nanoparticle ligand chemistry tunes intracellular targeting and ferroptosis-like cell death ()
Published October 27, 2026. A study published today in Nature Communications shows how changing the chemistry of nanoparticle surface ligands can alter their location inside cells and the type of cell-death response they produce. Diana V. Kolygina and colleagues investigated mixed-charge nanoparticles carrying mostly positive ligands and a smaller negative component. Keeping charge proportions constant, […]
- Biomimetic nanoparticles combine antibacterial and immune effects in rat periodontitis ()
Published October 27, 2026. A study published October 26 in the International Journal of Oral Science investigates a biomimetic nanoparticle for experimental periodontitis. Yufei Tang and colleagues combined minocycline-loaded gelatin particles with a hybrid coating made from neutrophil and macrophage membranes. The resulting system, NMm@MINO, released its antibiotic cargo in response to proteases. Laboratory tests […]
- Timing mRNA vaccine materials around surgery: a cancer immunotherapy framework ()
Published October 27, 2026. A Perspective published October 26 in Nature Reviews Materials argues that mRNA cancer vaccine materials should be designed around changing immune conditions, particularly before and after tumor surgery. Seong Dong Jeong and colleagues propose a framework called temporal immunoengineering. Instead of considering a nanocarrier only as a transport vehicle, they examine […]
- Lipid nanoparticles generate CAR NK cells in preclinical immunotherapy models ()
Published October 27, 2026. A research highlight in Nature Reviews Drug Discovery on October 26 draws attention to an October 13 Nature Biotechnology study on programming natural killer cells directly inside the body. Yuang Chen and colleagues engineered lipid nanoparticles with NK-cell-binding ligands to deliver messenger RNA encoding chimeric antigen receptors, or CARs. Lead formulations […]