Category: Biology
- CRISPR screen links MYD88–IRAK4 signaling to fungal-toxin damage in pig intestinal cells ()
Published October 30, 2026. A Communications Biology study published October 28 uses a genome-wide CRISPR knockout screen to investigate how deoxynivalenol, a fungal toxin, damages pig intestinal epithelial cells. The screen identified MYD88 and IRAK4 as leading contributors to susceptibility in the cultured-cell system. Exposure activated inflammatory signaling while reducing several antioxidant defenses and increasing […]
- Review examines macrophage lipid metabolism and bone remodeling ()
Published October 30, 2026. A new Bone Research review examines how lipid metabolism in macrophages influences the balance between bone breakdown and formation. The authors discuss fatty-acid oxidation and cholesterol metabolism as regulators of macrophage activation states. These immune-cell states can affect inflammation and the signals that shape bone remodeling. The review also considers emerging […]
- Study links mitochondrial complex IV dysfunction with Alzheimer’s-related damage ()
Published October 30, 2026. A study links mitochondrial complex IV dysfunction with Alzheimer’s-related pathology using human samples and experimental models. Researchers found connections with mitochondrial damage, synaptic loss and amyloid pathology, alongside genetic evidence implicating reduced COX11, a complex IV assembly factor. The findings support further investigation of mitochondrial mechanisms. They do not establish a […]
- Injectable Janus hydrogel supports endoscopic fistula repair in animal models ()
Published October 30, 2026. Researchers have developed an injectable hydrogel intended to seal gastrointestinal fistulas through endoscopic delivery. The Nature Biomedical Engineering study reports testing in rats and miniature pigs. The material combines a temperature-responsive polymer, PNIPAM, with gallium ions. Inspired by slug adhesive chemistry, it forms a gel with asymmetric, or Janus-type, adhesion: attachment […]
- Targeted RNA blockade reduces established atrial fibrosis in mice ()
Published October 30, 2026. Researchers blocked a specific interaction between microRNA-31-5p and calcitonin-receptor messenger RNA. In mice, this restored receptor expression, reduced established interstitial atrial fibrosis and modestly decreased atrial fibrillation burden. Human fibroblast experiments supported the pathway’s relevance. The intervention targeted one RNA interaction rather than broadly suppressing the microRNA. The findings are preclinical: […]
- 4-octyl itaconate promotes tolerogenic dendritic cells in experimental lupus ()
Published October 30, 2026. A new Cell Death Discovery study investigates 4-octyl itaconate, an itaconate derivative, as a way to alter dendritic-cell behavior in experimental lupus. In a chromatin-induced mouse model, treatment delayed disease onset and reduced proteinuria, anti-DNA autoantibodies and kidney injury. Laboratory and animal experiments indicated that the compound encouraged a tolerogenic dendritic-cell […]
- Aptamer biosensor detects mycoplasma-associated protein in T-cell culture ()
Published October 30, 2026. Researchers describe an electrochemical biosensor for detecting Mycoplasma hyorhinis contamination in human T-cell cultures. The device uses an aptamer that recognizes the microorganism’s p37 protein, offering a route to detection with limited sample preparation. In buffer and T-cell co-culture medium, the reported detection limit was approximately two cells per milliliter, while […]
- Aloperine triggers methuosis in preclinical lung cancer models ()
Published October 30, 2026. Aloperine disrupted vesicle processing and triggered methuosis, a form of cell death, in experimental lung cancer models. Researchers linked the effect to VPS34 and Armus/Rab7 signaling. Tests included cancer cell lines, patient-derived organoids and mouse xenografts. Combining aloperine with cisplatin enhanced antitumor effects. These preclinical results do not establish patient benefit […]
- Preprint reports functional recovery of vitrified, nanowarmed human-scale pig kidneys ()
Published October 30, 2026. An ATP-Bio research announcement dated October 15 reports recovery of human-scale pig kidneys after vitrification, storage at −150°C for up to one year and electromagnetic nanowarming. The associated study is a preprint and has not yet been peer reviewed. The approximately 100-gram kidneys represent a substantial increase in size over earlier […]
- Human cortical neurons with extensive genomic abnormalities decline around birth ()
Published October 30, 2026. A Nature study published October 28 reports evidence that neurons carrying extensive DNA copy-number abnormalities become much less common around birth in the human cortex. Researchers sequenced the genomes of 2,357 individual neurons from postmortem brains spanning fetal and postnatal life. Across two sequencing approaches, an average of 25.9% of prenatal […]