Category: Nanomedicine
- Review maps the shift toward tumor microenvironment regulation in nanotherapy ()
Published October 25, 2026. A bibliometric review published in Discover Nano on October 23 maps how nanotherapy research has increasingly focused on changing the tumor microenvironment, rather than using nanoparticles solely as drug carriers. The authors analyzed English-language articles and reviews indexed in Web of Science, covering publications through May 31, 2025. Citation networks, keywords […]
- Drug-Releasing Hydrogel Promotes Regulatory T Cells and Bone Repair in Mice ()
Published October 25, 2026. Researchers reporting in Nature Biomedical Engineering developed a drug-releasing hydrogel that encourages local regulatory T-cell activity and improves bone repair in an experimental skull-defect model. Gabriele Nasello and colleagues incorporated AS2863619, a cyclin-dependent kinase inhibitor, into collagen hydrogels. Loading the compound above its solubility limit reduced the initial burst of drug […]
- Near-Infrared-Activated Organic Framework Suppresses Tumors in Mouse Models ()
Published October 25, 2026. A study in Nature Communications reports an experimental light-activated material that suppressed tumors in female mice. Yu Xiao and colleagues developed a covalent organic framework built from thia-hexaphyrin units, designed to respond to near-infrared light. Under 808-nanometre laser irradiation, the metal-free framework generated reactive oxygen species and heat. These combined photodynamic […]
- Review Examines Lipid Nanoparticles for Experimental p53-Targeted Cancer Therapy ()
Published October 25, 2026. A new review in Cancer Nanotechnology examines lipid nanoparticles as delivery vehicles for experimental cancer therapies targeting the p53 tumor-suppressor pathway. Ricky Madison surveys several approaches: delivering messenger RNA to restore normal p53, using small interfering RNA to reduce mutant p53, delivering microRNA mimics that engage downstream pathways, and transporting gene-editing […]
- Bone-Targeted Nanozyme Suppresses Breast Cancer Metastases in Mouse Models ()
Published October 25, 2026. Researchers reporting in Advanced Materials have developed an experimental nanozyme designed to disrupt breast cancer growth in bone while limiting bone destruction. The material, called SPMMPA, was evaluated in mouse models of breast cancer bone metastasis. The particles combine a Prussian blue core, a porous silica layer and a manganese oxide […]
- NANORAD 2 Protocol Tests Nanoparticles With Radiotherapy for Brain Metastases ()
Published October 25, 2026. A newly published BMC Cancer protocol describes NANORAD 2, a randomized phase II study evaluating whether AGuIX nanoparticles can improve the effects of whole-brain radiotherapy for multiple brain metastases. Alexis Mercier and colleagues describe a multicentre comparison of radiotherapy alone with radiotherapy plus three intravenous nanoparticle injections. Eligible patients have brain […]
- Experimental nanoparticles temper inflammation in mouse sepsis models ()
Published October 22, 2026. A study published October 21 in Signal Transduction and Targeted Therapy reports that experimental nanoparticles improved short-term outcomes in mouse models of sepsis while shifting macrophages toward less inflammatory states. Xintong Lu and colleagues developed EONPs to combine modulation of STING immune signaling with inhibition of DHODH, an enzyme involved in […]
- Nanozyme hydrogel patch promotes diabetic wound repair in a pig model ()
Published October 18, 2026. A study published in Nature Communications on October 17 describes an experimental hydrogel patch designed to improve diabetic wound repair by changing macrophage metabolism. The researchers identified transketolase (TKT), an enzyme in these immune cells, as a regulator of blood-vessel regeneration. Loss of TKT increased amino-acid and fatty-acid breakdown, raised reactive […]
- Nanoscale imaging tracks antibody access to PD-L1 on individual cancer vesicles ()
Published October 17, 2026. An October 14 announcement from Kanazawa University, subsequently covered on October 16, highlights a method for watching antibodies interact with individual cancer-derived extracellular vesicles. The underlying Small Methods paper was published on September 17. Using high-speed atomic force microscopy in liquid, researchers followed antibody binding without fluorescent labels or chemical fixation. […]
- Human blood study compares RNA integrity across three mRNA vaccine platforms ()
Published October 17, 2026. An October 16 announcement from the Olivia Newton-John Cancer Research Institute describes a comparison of three mRNA vaccine platforms that could help researchers improve nanoparticle-based delivery. Working with the Peter Doherty Institute for Infection and Immunity, the team analysed 327 blood samples from 73 people who received Moderna, Pfizer or an […]